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Doctor's Best Cardiovascular Support - Sytrinol - 60 Softgels
Description: Science-based nutritionDietary supplementHelps maintain normal cholesterol levels in healthy individualsSytrinol is a formula derived from citrus and palm fruit extracts. It is a combination of citrus flavonoids and palm-sourced tocotrienols that can exert potent antioxidant effects. Sytrinol may have its major effect in the liver by acting there to balance the production of cholesterol. Research shows that it may be beneficial in helping to maintain normal cholesterol levels in healthy people.Benefits:Helps Maintain Normal Cholesterol Levels in Healthy Individuals PMFs: In Vitro and Animal ResearchResearch into the way in which PMFs modulate the production of cholesterol has revealed potential mechanisms of action. One such in vitro trial looked at the effect of tangeretin on human HepG2 cells a model commonly used to study the metabolism of lipids. This study found that when these cells are exposed to tangeretin the rate of Apoprotein B production rapidly decreases. Apoprotein B is a structural protein that controls the synthesis of LDL cholesterol from the cells. The study showed that tangeretin inhibited apoprotein B secretion in a dose-dependant manner.Another interesting component that was measured in this study was tangeretin's effectiveness in a lipid-rich environment. The cells were bathed in the tangeretin solution in the presence of a high amount of fat. In this environment tangeretin possessed the same ability to decrease apoprotein B secretion. It was thus shown that tangeretin can be effective at modulating the production of cholesterol in a variety of cellular environments.The researchers also showed that tangeretin may modulate the production of triglycerides on an enzymatic level. Triglycerides are an important component of the body's lipid profile and play a role in human health similar to other cholesterol components. Microsomal triglyceride transfer protein (MTP) and diacylglycerol acyltransferase (DGAT) are two components of triglyceride synthesis and transport within the cells. Tangeretin displayed inhibitory effects on MTP and suppressed the activity of DGAT thereby affecting triglyceride metabolism.A 2005 in vitro study looked at the effects of the second major PMF present in Sytrinol nobiletin. The results of this study showed that nobiletin in addition to being able to modulate the production of cholesterol has important free radical scavenging effects in the bloodstream.It is well known that the levels of cholesterol in the bloodstream are not the only factor in determining cardiovascular risk. Just as important if not more important is the state of oxidation of LDL cholesterol molecules. Oxidized LDL may deposit in blood vessels and increase cardiovascular risk factors. Nobiletin was shown to prevent oxidative damage to LDL molecules in this study. In purveying its potent antioxidant effect it keeps the LDL molecules healthy and

Store: PureFormulas Brand: Doctor's Best Price: USD 19.83


Doctor's Best Metabolic Support - Best L-Carnitine Fumarate 855 mg -
Description: Suitable for VegetariansScience-based nutritionDietary supplementHelps the body burn fat for energyHelps maintain normal cardiovascular healthL-Carnitine is a nutrient that promotes energy production in cells by transporting fatty acids into the mitochondrion an intracellular structure that generates metabolic energy in the form of ATP. In this role L-carnitine helps the body efficiently metabolize fat. Fumarate is a naturally occurring compound in the body. Fumarate serves as an intermediate in the Krebs cycle a key energy-producing process that takes place in the mitochondrion.The L-Carnitine Fumarate in this product is derived from a base of pharmaceutical grade L-Carnitine manufactured by a patented FDA-approved process. It is GMO-free pesticide-free and BSE safe.Helps the body burn fat for energy These statements have not been evaluated by the Food and Drug Administration (FDA) . These products are not meant to diagnosea treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Store: PureFormulas Brand: Doctor's Best Price: USD 40.28


Doctor's Best Joint Support - Glucosamine Chondroitin MSM - 240
Description: Science-based nutritionDietary supplementMaintains health joints and connective tissueContains sodium-free potassium stabilized glucosamine sulfate bovine chondroitin sulfate and pure MSM. (Lignisul MSM) . These statements have not been evaluated by the Food and Drug Administration (FDA) . These products are not meant to diagnosea treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Store: PureFormulas Brand: Doctor's Best Price: USD 28.45


Doctor's Best Detoxification - SAM-e 200 mg - 60 Tablets
Description: Suitable for vegetariansScience-based nutritionDietary supplementEnhances mood and neural functionPromotes joint comfort and mobilitySupports liver health and detoxificationOur SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active SS form per serving bar none.S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.Supplementing with SAMeThe manufacturing process of SAMe yields two forms the SS and the RS isomers. The SS isomer is the active form that mediates biochemical activity in the human body whereas the RS form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure SS form on the market.SAMe and Joint FunctionSAMe may enhance cartilage protection and promote the synthesis of proteoglycans essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement and promote joint comfort.SAMe and Neural HealthSAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine supporting cognitive function.SAMe and Liver FunctionSAMe enhances liver synthesis of glutathione an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins. These statements have not been evaluated by the Food and Drug Administration (FDA) . These products are not meant to diagnosea treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Store: PureFormulas Brand: Doctor's Best Price: USD 24.78


Doctor's Best Immune Support - EpiCor 500 mg - 60 Veggie Capsules
Description: Suitable for vegetariansScience-based nutritionDietary supplementEnhances immune system functionHigh metabolite immunogen that modulates immune system functionShown to activate natural killer (NK) cells in vitroEpicor is a natural immune-supportive compound that fits into the unique category of being a high metabolite immunogen. EpiCor is a nutritive dried yeast fermentate that supports cellular metabolism and modulates immune function. It is derived from the yeast Saccharomyces cerevisiae a non-pathogenic yeast commonly used in baking and brewing. In vitro laboratory data has shown that EpiCor beneficially influences cellular processes that impact immune health.Benefits:Initial Immune BenefitsThe initial Diamond V study involved laboratory analyses on blood drawn from 10 veteran workers with ongoing exposures to EpiCor during its manufacture and from 10 other company workers not exposed to the material. A summary of this study stated that the exposed workers had significantly higher levels of the protective antibody secretory IgA (sIgA) significantly lower levels of potentially harmful circulating immune complexes significantly higher natural killer (NK) cell activity with higher killing efficiency significantly higher CD4 (helper) to CD8 (suppressor) lymphocyte cell ratios (linked to improved immune capacity) and higher levels of the key antioxidant glutathione in their red blood cells. Subsequent larger randomized controlled trials (RCT) confirmed that EpiCor does benefit human immunity.Multiple Randomized Controlled Trials Confirm EpiCors BenefitsAfter four RCT (double-blind placebo-controlled clinical trials) EpiCor (500 mg taken once daily) is confirmed to produce consistent clinically important immune benefits. The first RCT found EpiCor added to the benefits of influenza vaccination for healthy subjects. Conducted in the U.S. Midwest during the cold and flu season (December 2006 to March 2007) it enrolled 116 healthy subjects aged 18 to 76 years all of whom had recently received the seasonal influenza vaccine. They were randomly allocated to receive either Epicor at 500 mg per day or a placebo for 3 months. Those subjects taking EpiCor experienced significantly fewer events with cold- or flu-like symptoms than did those taking placebo and the duration of symptoms was also significantly reduced (from an average 5 days to 4 days) . EpiCor significantly reduced hoarseness nasal congestion and weakness.The second RCT was also conducted in the U.S. Midwest during the flu season (January to March 2007) . Another 116 subjects were recruited also aged 18-76 years but not vaccinated against influenza. These subjects were randomly allocated to receive either EpiCor (500 mg/day) or a placebo for 3 months. The EpiCor group experienced significantly less incidence o

Store: PureFormulas Brand: Doctor's Best Price: USD 21.69


Doctor's Best Joint Support - Celadrin Complex with Glucosamine - 90
Description: Science-based nutritionDietary supplementSupports joint function & mobilityCeladrin Complex with Glucosamine provides a combination of Celadrin and sodium-free glucosamine sulfate. Celadrin is a proprietary blend of esterified fatty acids that have been shown to benefit joint function and flexibility. These statements have not been evaluated by the Food and Drug Administration (FDA) . These products are not meant to diagnosea treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Store: PureFormulas Brand: Doctor's Best Price: USD 16.34


Doctor's Best Cellular Support - Stabilized R-Lipoic Acid with
Description: Accelerate your glucose metabolism and energy production when you use Best Stabilized R-Lipoic Acid Veggie Caps from Doctor's Best. Research suggests that this coenzyme could have antioxidant properties that may help protect your body from free radical damage. This supplement also includes BioEnhanced Na-RALA for enhanced bioavailability over standard RLA. This dietary supplement from Doctor's Best contains R-Lipoic Acid (RLA) which is considered a universal antioxidant because it appears to be soluble in both water and fat. It is likely effective in delaying the degenerative effects of oxidative stress by negating the effects of damaging free radicals. Research also suggests that it promoteshealthy brain and nervous system functions. RLA appears to be a major metabolite required in the digestion of glucose which generates energy for your body. It could help restore and reactivate antioxidant nutrients like vitamin C and E and collaborate to fight against the detrimental effects of free radicals. Start taking Best Stabilized R-Lipoic Acid Veggie Caps from Doctor's Best and defend your body from free radical damage. These statements have not been evaluated by the Food and Drug Administration (FDA) . These products are not meant to diagnosea treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Store: PureFormulas Brand: Doctor's Best Price: USD 37.18


Doctor's Best Joint Support - Hyal-Joint 20 mg - 120 Capsules
Description: Hyal-Joint 120 CapsuleScience-based nutritionDietary supplementNourishes joint fluid for free and easy movementHyal-Joint is a patent-pending extract of rooster combs composed of 60% hyaluronic acid along with collagen and other glycosaminoglycans that form the structural components of connective tissue in joints. Essential for healthy joint function and mobility hyaluronic acid occurs naturally in the body as a part of synovial fluid which provides the liquid layer that cushions and lubricates joints.Puts the spring in your step and the bounce in your walkBenefits:Helps Maintain Healthy Smooth Joint FunctionThe effect of Hyal-Joint on joint function and comfort in humans was recently studied in a pilot clinical trial. The study subjects were men and women at least 40 years old who experienced noticeable deterioration of joint comfort on a regular basis.The participants were randomly assigned to take either 80 mg of Hyal-Joint or a look-alike placebo capsule every day for eight weeks. Each participants joint health and function status was evaluated at the beginning of the trial and again after four and eight weeks. Assessment was done using the WOMAC Index a self-administered questionnaire that measures 24 parameters of joint function and a 36-question survey of physical and mental health and well-being. Statistical analysis of the data showed Hyal-Joint to be efficacious for improving physical function joint comfort and quality of life.Nourishes Joint Fluid for Free and Easy MovementAs described earlier hyaluronic acid is necessary for the synovial fluid to perform its lubricating function in joints. Studies on the intra-articular injection of hyaluronic acid into joints suggest that exogenous HA potentiates endogenous production in synovial fibroblasts (synoviocytes) . In a cell culture (in vitro) study Hyal-Joint effectively stimulated endogenous synthesis of hyaluronic acid in synoviocytes.It has been observed that a diminished content of hyaluronic acid in jointswith a concomitant loss of its elastic lubricating benefits occurs in tandem with sub-optimal joint health and function. As joint health declines the amount of hyaluronic acid in synovial fluid (intra-articular content) is reduced. Hyal-Joint was studied for its ability to increase the hyaluronic acid concentration in joints of horses with poorly functioning joints. In a small pilot trial oral administration of Hyal-Joint for 60 days measurably increased both the quantity and quality of hyaluronic acid of the tarsocrural joint (the articulation between the tarsal bone of the foot and the tibia and fibula) while at the same time improving walking ability. These statements have not been evaluated by the Food and Drug Administration (FDA) . These products are not meant to diagnosea treat or cure any dis

Store: PureFormulas Brand: Doctor's Best Price: USD 16.73


Doctor's Best Nervous System Support - Best L-Tryptophan TryptoPure
Description: L-tryptophan is an essential amino acid (protein building block) in human nutrition. Essential amino acids are not synthesized by the body and must be obtained in the diet. The L-tryptophan in this product is manufactured and tested for purity according to the Japanese Pharmacopeia (JP) and the United States Pharmacopeia (USP) standards. These statements have not been evaluated by the Food and Drug Administration (FDA) . These products are not meant to diagnosea treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Store: PureFormulas Brand: Doctor's Best Price: USD 19.11

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